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Image: ADOLFO GARCIA-SASTRE, PhD

 

ADOLFO GARCIA-SASTRE, PhD

Dr. García-Sastre is a co-founder of Vivaldi and a Scientific Advisor to the company. Dr. García-Sastre is a Professor in the Department of Microbiology and is the Director of the Global Health & Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai. He is also Principal Investigator for the Center for Research on Influenza Pathogenesis, one of five NIAID Centers of Excellence for Influenza Research and Surveillance. For the past 20 years, his research has focused on the molecular biology of influenza viruses and other negative-strand RNA viruses. Dr. García-Sastre's contributions to the influenza virus field include collaboration with Dr. Peter Palese in the development of reverse genetics techniques which allowed the generation of recombinant influenza viruses from plasmid DNA, generation and evaluation of influenza virus vectors as potential vaccine candidates against different infectious diseases, and identification of the role of influenza NS1 protein in the inhibition of the host type 1 interferon system. Dr. García-Sastre's research provided the first description and molecular analysis of a viral-encoded interferon antagonist among negative-strand RNA viruses. This research led to the generation of candidate live attenuated influenza vaccines LAIVs) containing defined mutations in their interferon antagonist protein. Dr. García-Sastre's research has resulted in more than 100 scientific publications and reviews. He is an editor for the Journal of Experimental Medicine and PLoS Pathogens, and is a member of the editorial boards of the Journal of Virology, Virology, Journal of General Virology, and Virus Research. Dr. García-Sastre earned his PhD at the University of Salamanca and completed his postdoctoral work in the laboratory of Dr. Palese at Mount Sinai School of Medicine.

 

   
 


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