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Dr. Garcia-Sastre is a co-founder of Vivaldi and an advisor to the company. Dr. García-Sastre is Professor in the Department of Microbiology and Co-Director of the Global Health and Emerging Pathogens Institute at Mount Sinai School of Medicine. He is also Principal Investigator for the Center for Research on Influenza Pathogenesis (CRIP), one of five NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS). For the past 20 years, his research interest has been focused on the molecular biology of influenza viruses and several other negative strand RNA viruses. Dr. Garcia-Sastre's contributions to the influenza virus field include collaboration with Dr. Palese in the development of reverse genetics techniques, allowing the generation of recombinant influenza viruses from plasmid DNA, generation and evaluation of influenza virus vectors as potential vaccine candidates against different infectious diseases, and identification of the role of influenza NS1 protein in the inhibition of the host type 1 interferon system. Dr. Garcia-Sastre's studies provided the first description and molecular analysis of a viral-encoded interferon antagonist among negative-strand RNA viruses. These studies led to the generation of candidate live attenuated influenza vaccines containing defined mutations in their interferon antagonist protein. Dr. Garcia-Sastre is a co-leader of the basic research component on Viral Therapeutics and Pathogenesis of the NIAID-funded Northeast Biodefense Center. He has been a member of the Vaccine Study Section and of the VirB Study Section of the NIH, and is an editor for the Journal of Experimental Medicine, PLoS Pathogens and Journal of Virology. He is also on the editorial boards of Virology, Journal of General Virology and Virus Research. His research has resulted in over 200 scientific publications and reviews. Dr. García-Sastre earned his PhD at the University of Salamanca and completed his postdoctoral work in the laboratory of Dr. Palese at Mount Sinai.



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